If you take the guitar to the plane, you don't have much to worry about. The cabin pressure and temperature are normal. The air is dry and recycled, but as long as you have a humidifier in your guitar and you take your own vitamins, you have nothing to worry about. But if your guitar is in the cargo compartment below. Dramatic temperature and humidity changes can destroy your instrument.
For all kinds of guitars and guitar boxes, I don't have a one-size-all prescription. (Some people will tell you to loosen the strings to avoid the extreme tension, or to pad things in the box, such as newspapers or socks, etc.). But my advice is to check your guitar and guitar maker's advice and see what they say about safe travel.
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